Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. View abstract. Sloan, R. S., Kastan, B., Rice, S. I., Sallee, C. W., Yuenger, N. J., Smith, B., Ward, R. A., Brier, M. E., and Golper, T. A. View abstract. View abstract. Saneian H, Khalilian L, Heidari-Beni M, et al. Ahmad S, Robertson HT, Golper TA, et al. View abstract. This thread is archived Clin Ter. View abstract. In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. Diabetologia 1995;38(1):123. View abstract. 2008;26(3):388-4. 2008;14(2):149-151. It is usually taken in doses from 1000 to 2000 milligrams per day . Bodea, F., Bocea, A., and Decea, N. [L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia]. Metab Brain Dis 2011;26(4):281-289. Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. View abstract. Sole MJ, Jeejeebhoy KN. View abstract. Therapeutic evaluation of L-carnitine in Egyptian children with dilated cardiomyopathy. Wadman, R. I., Bosboom, W. M., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. View abstract. Myocardial response to pretreatment with L-carnitine in patients with cardiac valve replacement. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. L-carnitine is best known as a fat burner, but the overall research is mixed. Zilleruelo, G., Novak, M., Hsia, S. L., Goldberg, R., Abitbol, C., Monkus, E., and Strauss, J. Pediatr.Res. Medically reviewed by Drugs.com. View abstract. Maebashi, M., Kawamura, N., Sato, M., Imamura, A., and Yoshinaga, K. Lipid-lowering effect of carnitine in patients with type-IV hyperlipoproteinaemia. Nephron 38 (1984): 120-4, 6. Am.J Kidney Dis 1999;34(4):678-687. View abstract. View abstract. Payne, C., Wiffen, P. J., and Martin, S. Interventions for fatigue and weight loss in adults with advanced progressive illness. J Am Acad.Dermatol. 11-15-2008;102(10):1413-1417. Side effects may include nausea, gastrointestinal discomfort, bloating, diarrhea, hives, lower back pain, leg restlessness, numbness, rash, endocrine changes, increased inflammatory response, increased blood urea nitrogen, severe tissue necrosis and venous irritation. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38. View abstract. View abstract. J Pediatr.Gastroenterol.Nutr. Hepatology 1997;25:148-53. PLoS One. Current issues regarding treatment of mitochondrial fatty acid oxidation disorders. Carlsson, M., Forsberg, E., and Thorne, A. Observations during L-carnitine infusion in two long-term critically ill patients. Korean J Gastroenterol. 2002;4(1):61-66. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. 2011;22(6):1155-1159. View abstract. Bohles H, Noppeney T, Akcetin Z, and et al. Scand.J Clin Lab Invest 1985;45(3):193-198. Martina, B., Zuber, M., Weiss, P., Burkart, F., and Ritz, R. [Anti-arrhythmia treatment using L-carnitine in acute myocardial infarct]. Clin Ter. View abstract. However, one analysis of nine studies mostly in obese individuals or older adults found that people lost an average of 2.9 pounds (1.3 kg) more weight while taking L-carnitine (29). L-Carnosine is known as the ' longevity molecule'. 2010;106(8):1181-1185. View abstract. Effects of L-carnitine on leukocyte function and viability in hemodialysis patients: A double-blind randomized trial. View abstract. 2010;610:285-308. A., Kraemer, W. J., Vingren, J. L., Hatfield, D. L., Fragala, M. S., Ho, J. Y., Maresh, C. M., Anderson, J. M., and Volek, J. S. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. Bellinghieri G, Savica V, Barbera CM, Ricciardi B, Egitto M, Torre F, Valentini G, D'Iddio S, Bagiella E, Mallamace A, et al. 1990;34(6):501-505. Zhang, X. L. and Ge, H. Clinical observations on treating ischemic cardiomyopathy using Fasudil and L-carnitine. View abstract. Amino.Acids 2008;35(2):419-423. Anesth.Analg. Novak M, Monkus EF, Buch M, and et al. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. Corbucci, G. G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. View abstract. Dig.Dis. View abstract. View abstract. Research shows that your levels tend to decline as you age (63, 64). 2010;32(8):669-672. Carnosine supplements are available as powders and capsules. Angiology 1989;40(10):857-862. Ross, C., Morriss, A., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., and El-Toukhy, T. A systematic review of the effect of oral antioxidants on male infertility. View abstract. 2010;15(2):200-211. Bella R, Biondi R, Raffaele R, Pennisi G. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. Muscle carnitine deficiency: adult onset lipid storage myopathy with sensory neuropathy. Tell your doctor if you are pregnant or plan to become pregnant. View abstract. A multicenter study of nutraceutical drinks for cholesterol (evaluating effectiveness and tolerability). "So there's a link . J Pain Symptom Manage 2006;32:551-9. Guevara-Campos, J., Gonzalez-Guevara, L., Parada, Y., and Urbaez-Cano, J. Propionyl-L-carnitine: Studies have shown that propionyl-L-carnitine combined with Viagra might improve erectile function better than sildenafil alone. Pediatr Cardiol 2005;26(5):574-577. Effect of L-carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis. View abstract. J Strength.Cond.Res. Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a . Clin Ter 3-31-1990;132(6 Suppl):479-510. J Cancer Res.Clin Oncol. Sum CF, Winocour PH, Agius L, and et al. Eur J Appl Physiol Occup Physiol 1985;54:131-5. View abstract. Mikhailova, T. L., Sishkova, E., Poniewierka, E., Zhidkov, K. P., Bakulin, I. G., Kupcinskas, L., Lesniakowski, K., Grinevich, V. B., Malecka-Panas, E., Ardizzone, S., D'Arienzo, A., Valpiani, D., Koch, M., Denapiene, G., Vago, G., Fociani, P., Zerbi, P., Ceracchi, M., Camerini, R., and Gasbarrini, G. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Biomed Pharmacother. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Ann N Y Acad Sci 2004;1033:117-31. View abstract. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. 2004;34(6):615-623. J Infect Dis 1997;176:1517-23. Protective effect of intravenous levocarnitine on subsequent-month hospitalization among prevalent hemodialysis patients, 1998 to 2003. Nephron 1989;51(2):237-242. View abstract. Acute systemic and splanchnic haemodynamic effects of L-carnitine in patients with cirrhosis. View abstract. nausea or vomiting Less common Abdominal discomfort body odor depression dizziness impaired vision loss of appetite or weight swelling in hands, lower legs, and feet tingling sensation weakness For Healthcare Professionals Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. View abstract. Sabry, A. Eur.Urol. 2006;72(3):231-237. View abstract. . 2008;29(2):261-266. View abstract. Eggs are so nutritious that they're often referred to as "nature's multivitamin." View abstract. Curr Ther Res 1980;27(2):208-216. December 1999. View abstract. View abstract. Int.J Sport Nutr.Exerc.Metab 2011;21(5):385-397. View abstract. J Inherit.Metab Dis 11-19-2010; View abstract. Are There Side Effects to L-Carnitine Supplementation? J.Nutr.Health Aging 2010;14(3):224-230. Blood 1998;91:3817-24. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. Guarnieri, G. F., Ranieri, F., Toigo, G., Vasile, A., Ciman, M., Rizzoli, V., Moracchiello, M., and Campanacci, L. Lipid-lowering effect of carnitine in chronically uremic patients treated with maintenance hemodialysis. L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial. (Pakistan) 2006;6(5):800-805. View abstract. Turpeinen, A. K., Kuikka, J. T., Vanninen, E., Yang, J., and Uusitupa, M. I. Ye, J., Li, C. J., and Liu, J. H. [A clinical analysis of methylmalonic acidemia in adolescents]. View abstract. L-Carnitine Supplement Side Effects. Some studies demonstrate a potential for reducing blood pressure and the inflammatory process associated with heart disease (23, 39). Eur.J Haematol. View abstract. Along with its needed effects, levocarnitine (the active ingredient contained in L-Carnitine) may cause some unwanted effects. View abstract. 2010;14(4):498-504. Krahenbuhl S. Carnitine metabolism in chronic liver disease. Cardiovasc.Drugs Ther 2009;23(4):301-306. Does carnitine cause high blood pressure? Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). J Med.Toxicol. Be sure to have your blood checked regularly. B., and Wang, Y. X. 12-3-1999;87(4):366-368. View abstract. View abstract. Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., and Karagenc, N. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. The effect of L-carnitine (carnitene) on myocardial metabolism of patients with coronary artery disease. 2-8-2006;107(1):54-60. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. View abstract. Int J Vitam Nutr Res 1995;65:211-4. Indian J Clin Biochem 1992;7:19-21. Nephron 1997;75(3):372. J Androl 2012;33(2):170-175. Tanphaichitr N. In vitro stimulation of human sperm motility by acetylcarnitine. View abstract. View abstract. Calabrese, V., Colombrita, C., Sultana, R., Scapagnini, G., Calvani, M., Butterfield, D. A., and Stella, A. M. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function. Cochrane.Database.Syst.Rev. View abstract. Am.J Cardiol. View abstract. Z., Wang, L. X., Liu, H. Z., Qi, X. W., Wang, X. H., and Ren, H. Z. L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Brass EP. Glycine Propionyl L-Carnitine (GPLC) is used to alleviate intermittent claudication and blood flow issues. J Inherit.Metab Dis 2010;33(5):555-561. Garzya G, Corallo D, Fiore A, et al. View abstract. The role of carnitine supplementation during valproic acid therapy. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Acetyl-L-carnitine as a therapeutic agent for mental deterioration in geriatric patients (Double-blind placebo controlled study). J Mol.Histol. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. It can cause side effects such as stomach upset, heartburn, diarrhea, and seizures. High levels of TMAO are linked to an increased risk of atherosclerosis a disease which clogs your arteries (59, 60).